We did a baseline measurement on Week 0 before the stress and cannabis exposure started and subsequent measurements on Week 4 and Week 8 of the experimental procedures Figure 1. Onaivi , M. Self-grooming is a complex innate behavior of rodents which is regulated by several neural circuits. Murphy, M. Psychiatry 16, —
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Adult neurogenesis - Wikipedia
One possible explanation for the fact that previous studies did not report on such abnormal looking cells after cannabinoid treatment is that our analysis was much more careful and thorough compared to the previous studies. Cell Stem Cell 8: — In addition, endocannabinoid signaling has been shown to promote astroglial differentiation of cortical neural progenitor cells and of adult hippocampal progenitors . The differentiation process in neurons is a complex phenomenon involving multiple changes in electrophysiological characteristics as well as changes in morphology characterized by neurite dendritic and axonal outgrowths. Results of the cognitive tests: Neither stress, nor marijuana exposure affected the cognitive abilities of the animals. Adult-born neurons in the dentate play an essential role in normal cognitive functioning and in specific forms of learning Denny et al. In addition, in a different perspective, brain injuries, such as seizures, head traumas and stroke, result in stimulation of neurogenesis, and this has been proposed as an endogenous attempt to repair and reduce brain damage .